Q arcana + R2, double dot source
Sorceress - Lv.120
Anything with Q2/R2/W3/R3 could be used. Best runes set would be W3+R3, or W3+Q2/R2.
Either focus q2 or use some r2 runes still give the final dps similar to each versions anyway.
You can choose between secret t3 (double w3 effect), or secrett t4 (making e1 eats less stacks and 100% chance to activate).
T3 gives more damage when you stack W3, but less chance of having Q2 & R2 & R3 all the time, plus harder normal waves clearing. As so, it's not really healthy.
You can use her secret T4 however, to have better control over your runes and less Rng.