Prepare to buy a new R key
Astral Ranger - Lv.120
The gear is all what you need, despite mine not all being as high of a level as I'd like, this is the basis for it. Obviously you can add second gems if you'd like, but that's mainly superfluous as this setup already provides everything you need to breeze through almost any content.
The gist is to stack as much ability damage, R1 runes, element damage, and cosmic damage as possible. The gear, gems, and glyph setup maximize your damage output while erasing your cooldown for R, as well as making it not require a channel.
The 10 points into W4 is literally only there to get the extra boost out of your glyphs. With 10 points into all T4 runes, your glyph gives you 80% extra cosmic damage, which outperforms the typically used 50% from all elements.
The effects of Space Tech Vest and the Desert Kabuto coupled together make you basically immortal. While "channeling" R, you are completely immune to damage, and since the channel lasts longer than the 1.4 second cooldown, you are immortal as long as youre smashing R every time the cooldown is up. The only tricky thing is staying mobile and dodging silences and stuns, because if you catch a stun longer than the channel, pretty much anything will oneshot you, as this build has roughly 3k hp.
The only thing this build cannot deal with is Golden Skullbones. It has literally no way to deal with them as they are permanently magic immune, and the only source of damage this build has is smashing R like it owes you money. The only time this is a big deal is if you have to clear the Treasure Room in Winterblight Castle, because you have to kill the Golden Skullbones to progress to the next room. Even in the Pit of Trials, I've simply kited the Golden Skullbones in the hidden room, all the way to the boss fight, while simply ignoring them since they can't damage me either. Winterblight Castle, presuming you don't get the Treasure Room, is a 20min clear. Sea Fort is 30ish. Equinox Redfall in well under an hour.
The best thing about this build is that other than the glyphs, it's extremely cheap. Even with just a mythical weapon with R1 on it, you can still shred all content as long as you have the gear and a handful of ordinary gems. This was my first end-game build, and with it I was able to easily farm all content to outfit 4 other characters in a couple of days. With higher level gear, better rolls, and higher quality gems, this build will only move faster and faster. It already does 4-5m dps in its current welfare state, and isn't even fully optimized.