Moistbringer (This Build is Bullhit)
Duskbringer - Lv.120
20m+ edps, ~99% uptime on physical damage immunity and magical damage immunity, great clear speed for ALL content
Core concept: The core of this build utilizes Iron Treads and a Moon Shard to maintain 100% uptime on Seven Visions, and Blue Rain gloves to never miss and deal out aoe pure damage. During the 7 procs, you are immune to physical AND magical damage, which means that as long as you're smashing R like it insulted your wife, you are basically invincible for 2.95 out of every 3 seconds. You also dish out HUGE chunks of AOE damage that are physical, magical, and pure all at the same time. It's like riding Splash Mountain at Disney World, except everything dies.
Gear: The only must-haves on this build are the boots, trinket, and gloves.
Boots- Do you like smashing things in the skull constantly? Too slow. By the time you answered that, Moistbringer already caved the back of your head in 7 times and teleported into the next room. Iron Treads of Destruction with R3 rune and double strength.
Trinket- Do you like constantly teleporting to enemies and donkey punching them, and never ever having to stop? Moon Shard with R3 rune and double strength.
Gloves- These bad boys are Moistbringers namesake. Send constant tsunamis out in all directions for millions of aoe pure damage. As a bonus pretzel, they make it so that you CANNOT MISS any of your attacks. TA's in mid Sea Fort? Toast. Skeleton Kings at Crimsyth Castle? Dead, again. Riki's and AM's of all shapes and sizes? You probably won't even notice that they were there before Moistbringer blinks to them and one-shots them with roaring, watery fury. Blue Rain with Q2 and double strength. The scaling of Q2 offers more damage than any other possible roll on these gloves.
Weapon- Warden's Bone Mace is your best option here due to the Ghost Damage %, but if you get some really lucky runes on a purple weapon, they can work as well. Aim for Q2, R3, or strength rolls on the Warden's Mace.
Chest- Ruby Dragon armor with triple strength is highly recommended as it is a large dps increase over Plate of Leon, but if you're in a pinch or on a budget, Plate of Leon will function just fine and is likely your second best option. There are a couple of meme options as well, like Avalanche Plate if you just want to perma-stun everything, but all other options are significant dps decreases compared to Ruby Dragon armor.
Helm- Iron Colossus rolled with str/armor/str (the 2nd slot will only roll armor) is by far your best option, and your biggest source of dps. Other viable but not as good options are Water Deity Crown, which will give you slightly more pure damage but significantly less physical, and Cloak of the Cimmerian Priesthood which will let you perma-fear everything and provide 100% uptime on crowd control. Using the Cloak however will make things run away from you, and I find that annoying as it can drastically lower your speed and clear times in some cases since things won't bunch up and let you utilize your aoe to its fullest extent.
Glyphs: Okay look, Duskbringer's glyphs are currently a complete effing mess. At the time of writing this guide, the glyphs I'm using are his best options. If his 6-2 glyph gets fixed, it would be a viable option, and open up some REALLY cool combos like using Helm of the Silent Templar for a HUUUUGE damage boost, or using his 1-2 glyph in a tanky build. If his E4 rune ever gets fixed to apply to himself and not just allies, then his immortal glyph becomes a virtual must-have as it will give you a free res every 22 seconds on the rare occasion that you die with this build.
Gems: A truly great thing about this build is that it really only requires ~8k gemstones (4 ordinary and 1 pristine) to shine and be perfectly endgame viable. Anything over that just adds more to your dps and is a pure luxury for faster boss fights. With 4 ordinary gems, 1 pristine (the 1 pristine is a 100% absolute must-have for your Moon Shard, to maintain 100% uptime on your Seven Visions) gem, and average rolls, you are still near invincible and do 5m+ dps. The must-have gems are Amethyst in helm, Ruby and Emerald in chest, Amethyst in gloves, and Pristine Sapphire in trinket. The rest are up to you, but I feel that the gems I've used are fully optimized in the current patch.
Runes: The only negotiable runes here are Q1 and W3. W3 can be swapped for E2 if you want more survivability, but that is a much more active playstyle, and is really only useful for killing the Barbed Sea Beasts or Ol' Spiny. Outside of that, I prefer W3 personally as it turns any dots that may sneak onto you as a heal, and negates a portion of all the rare damage you'll take. Unless you plan on maintaining your shield stacks by constantly casting E in between your R's, you're better off just taking the heal over the negation (ESPECIALLY at low levels. Rushing W3 makes Moistbringer basically immortal up to ~lvl90). If E4 ever gets fixed, you will IMMEDIATELY take 4 points out of Q1 and put them into 1 level of E4, as well as swapping his Glyph of Grand Strength for his Immortal Glyph.
Pros: There is no content or boss that this build cannot handle, with the exception of Challenges that don't let you use R. You are tanky by way of near constant damage immunity, kill everything super fast with huge 700 radius aoe damage that is phys, mag, AND pure all at the same time, and teleport from enemy to enemy so fast that I promise on more than one occasion you will lose track of your hero. You do CRAZY instances of damage thanks to your hit proccing, the R proccing, the helm damage proccing, the gloves damage proccing, and Q1 ticks proccing. Dock Spawner, Tombstones, Blue Doom, and Thadelus all get MELTED by this build, and you probably won't even notice that they aren't dying as fast as everything else. We're talking DOZENS of instances with one press of R.
Cons: As mentioned above, the Barbed Sea Beasts and Ol' Spiny are a problem. They return Pure damage onto you, and due to the fact that R teleports to enemies at random, you have no choice about smacking them in the face and exploding yourself into large, wet steaks on occasion. My best advice is to just anticipate that fact and plant a respawn flag before you employ R for some mutually assured destruction, or to spec into E2 out of W3 if you find it that annoying.
Note: epds is "effective damage per second". I test ALL of my builds on dummies that have 7k armor and 7k magic armor, so that you're seeing real world combat numbers on boss level armors, and not just some inflated "100m+ dps!" build that actually only hits for 2m dps on anything not naked and asleep.